|
KMID : 1123920040180020538
|
|
Korean Journal of Oriental Physiology and Pathology
2004 Volume.18 No. 2 p.538 ~ p.543
|
|
|
Effect of Puerariae Radix on c-Fos and c-Jun Expressions in Ischemic Damaged Hippocampus of Rats
|
|
Jo Gyu-Chil
Kim Youn-Sub
|
|
|
Abstract
|
|
|
Objective : This study investigated a neuroprotective effect of Puerariae Radix on cerebral ischemia.
Method : The global cerebral ischemia was induced by bilateral common carotid arteries occlusion under hypotension (40mmHg) in Sprague-Dawley rats. After the treatment of Puerariae Radix extract, changes of c-Fos and c-Jun expressions, immediate early genes expressed by cerebral ischemia, in the hippocampus were observed immunohistochemically.
Result: The results obtained are as follows; The significant increases of c-Fos and c-Jun expressions were observed in the hippocampus of the ischemic damaged rat brains. Then Puerariae Radix treatment demonstrated significant decreases of c-Fos and c-Jun expressions in CA1 region and dentate gyrus as compared with control group. On the upregulated c-Fos expression induced by cerebral ischemia, Puerariae Radix treatment demonstrated significant decreases of c-Fos expressions in CA1 region (P<0.01) and dentate gyrus (P<0.05) as compared to the control group, but there were not a significant changes in CA2 and CA3 regions of the hippocampus. On the upregulated c-Jun expression induced by cerebral ischemia, Puerariae Radix treatment demonstrated significant decrease of c-Jun expression in CA1 region (P<0.05) as compared to the control group, but there were not a significant changes in CA2, CA3, and dentate gyrus of the hippocampus.
Conclusion : These results suggested that Puerariae Radix reveals the neuroprotective effect through the reduction of immediate early genes, c-Fos and c-Jun, induced by cerebral ischemia.
|
|
|
KEYWORD
|
|
|
Puerariae Radix, c-Fos, c-Jun, cerebral ischemia
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|